人急性髓系白血病细胞MOLM-14

细胞名称

人急性髓系白血病细胞MOLM-14

货物编码

BFN60810333

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研   3类

培养体系

90%DMEM+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人急性髓系白血病细胞MOLM-14取自20岁男性外周血，该细胞源于DSMZ

注释

Doubling time: 3-4 days (PubMed=9305600); ~50 hours (DSMZ).

Omics: Deep quantitative phosphoproteome analysis.

Omics: H3K79me1 ChIP-seq epigenome analysis.

Derived from sampling site: Peripheral blood.

基因突变

KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) gene fusion (PubMed=9305600).

FLT3 internal tandem duplication (FLT3-ITD) (PubMed=12529668).

HLA信息

/

STR信息

Amelogenin        X,Y

CSF1PO        10,12

D2S1338        23,25

D3S1358        15

D5S818        10,11

D7S820        10,12

D8S1179        13,14

D13S317        10,11

D16S539        10,11

D18S51        13,15

D19S433        12,14

D21S11        30,31

FGA        21,23

TH01        7

TPOX        8

vWA        16,17

参考文献

PubMed=9305600; DOI=10.1038/sj.leu.2400768

Matsuo Y., MacLeod R.A.F., Uphoff C.C., Drexler H.G., Nishizaki C., Katayama Y., Kimura G., Fujii N., Omoto E., Harada M., Orita K.

Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).

Leukemia 11:1469-1477(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12529668; DOI=10.1038/sj.leu.2402740

Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.

FLT3 mutations in acute myeloid leukemia cell lines.

Leukemia 17:120-124(2003)

PubMed=21552520; DOI=10.1371/journal.pone.0019169

Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S., Tucker M., Kornhauser J., Ren J., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.

Survey of activated FLT3 signaling in leukemia.

PLoS ONE 6:E19169-E19169(2011)