人脑髓母细胞瘤细胞ONS-76

细胞名称

人脑髓母细胞瘤细胞ONS-76

货物编码

BFN60808588

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研      3类

培养体系

DMEM高糖培养基+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人脑髓母细胞瘤细胞ONS-76取自2岁女性供体。该细胞源于JCRB

注释

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

Part of: COSMIC cell lines project.

Doubling time: 18.6 hours (CelloPub=CLPUB00094; PubMed=2504489; PubMed=2818910); ~24 hours (lot 08192008), ~32 hours (lot 12042014) (JCRB).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep RNAseq analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

基因突变

Heterozygous for NRAS p.Gln61Arg (c.182A>G) (CCLE; Cosmic-CLP).

TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).

Has no TP53 mutation (CCLE; Cosmic-CLP).

HLA信息

/

STR信息

Amelogenin        X

CSF1PO        10,12

D2S1338        17,19

D3S1358        15

D5S818        9,10

D7S820        11,12

D8S1179        10

D13S317        8,13

D16S539        9,10

D18S51        14,21

D19S433        14,15.2

D21S11        29,30.3

FGA        24

Penta D        12,13

Penta E        15,16

TH01        9

TPOX        8

vWA        14,16

参考文献

PubMed=22951319; DOI=10.1093/jrr/rrs078

Sun L., Moritake T., Zheng Y.W., Suzuki K., Gerelchuluun A., Hong Z., Zenkoh J., Taniguchi H., Tsuboi K.

In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76.

J. Radiat. Res. 54:61-69(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028

Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.

In vitro models of medulloblastoma: Choosing the right tool for the job.

J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004

Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)